fbpx

Australia Scraps Covid-19 Vaccine That Produced H.I.V. False Positives

Details
Category: HIV based Lentiviral Vectors
Created: Friday, 11 December 2020 16:58
Written by Mike Ives - NY Times

Prime Minister Scott Morrison of Australia on Friday canceled a large order of a developed coronavirus vaccine after not having the approval from the Therapeutic Goods Administration, the country’s drug regulator.

“The advice that we have received, and the National Security Committee of Cabinet met this week and made the final decision yesterday, is that the University of Queensland vaccine will not be able to proceed based on the scientific advice, and that will no longer feature as part of Australia’s vaccine plan. And the decision we’ve taken should give Australians great assurance that we are proceeding carefully. We are moving swiftly, but not with any undue haste here. At the end of the day, the Therapeutic Goods Administration like with any vaccine in Australia, it must have their tick-off — without the tick, there’s no jab when it comes to vaccines in this country. That is true for the Covid-19 vaccine, as it is true for any other vaccine that is administered here in Australia.” “Clearly, the discontinuation of Q vaccine by mutual agreement, it was likely to be a promising vaccine. It was likely to work. But we knew that we didn’t want to have any issues with confidence, and this false positive test may have caused some confusion and lack of confidence. But it was a very, very good technology. It was looking like it was going to make antibodies, and it probably would have worked very well as a vaccine.”

Australia on Friday canceled a roughly $750 million plan for a large order of a locally developed coronavirus vaccine after the inoculation produced false positive test results for H.I.V. in some volunteers participating in a trial study.

Of the dozens of coronavirus vaccines being tested worldwide, the Australian one was the first to be abandoned. While its developers said the experimental vaccine had appeared to be safe and effective, the false positives risked undermining trust in the effort to vaccinate the public.

Prime Minister Scott Morrison on Friday said that his government would compensate for the loss of 51 million doses it had planned to buy from the Australian consortium in part by increasing orders of vaccines made by AstraZeneca and Novavax. The government has said it plans to begin inoculating citizens by March.

 

 

The Australian setback showed the missteps that can inevitably occur when scientists, during a pandemic that has killed more than 1.5 million people, rush to condense the usual yearslong process to develop vaccines into a matter of months.

But just as the Australian scientists made their announcement, the fruits of that race became clearer. The United States moved a step closer to issuing its first approval for a Covid-19 vaccine, as a panel of experts who advise the Food and Drug Administration endorsed a Pfizer vaccine that is already in use in Britain.

 

The trouble that arose with the Australian vaccine, developed by the University of Queensland and the biotech company CSL, was related to its use of two fragments of a protein found in H.I.V.

The protein formed part of a molecular “clamp” that researchers placed on the spikes that surround the coronavirus and allow it to enter healthy cells. The clamp stabilizes the spikes, allowing the immune system to respond more effectively to the vaccine. 

 

Because H.I.V. tests could not be rapidly re-engineered to account for this, the researchers decided to abandon development of the vaccine. Proceeding could have led to 

Early experiments on hamsters showed that the vaccine protected them from the coronavirus. When Phase 1 trials on humans began in July, the 216 volunteers were “fully informed of the possibility of a partial immune response” to the clamp, the University of Queensland and CSL said in a statement on Friday.

The mistake, said John P. Moore, an immunologist at Weill Cornell Medical College in New York, was an “honest error” that cost money, not human lives.

“I’m sure a lot of people are very embarrassed by it,” Professor Moore said. “It’s not great to be associated with a mistake like this. But when you’re running at 90 miles an hour, sometimes you trip.”

The University of Queensland vaccine was one of several under development that contain a coronavirus protein that prompts a response from the immune system. Protein-based vaccines have a longer track record than some of the newer approaches used by competing coronavirus vaccines, such as those based on viral genes or so-called adenoviruses.

Prominent protein-based vaccines include one made by the Maryland-based Novavax, which is in Phase 3 trials, and another from Clover Biopharmaceuticals of China that is in Phase 1 trials.

In the case of the Australian vaccine, it was found to produce a strong immune response and caused no serious side effects in the Phase 1 trial, according to the scientists’ statement. But proceeding with the vaccine trial would have required “significant changes” in longstanding H.I.V. testing procedures, they said.

 

“Doing so would set back development by another 12 or so months, and while this is a tough decision to take, the urgent need for a vaccine has to be everyone’s priority,” Paul Young, a virologist at the university who helped lead the vaccine effort, said in the statement. He did not immediately respond to a request for comment on Friday afternoon.

Australia’s health minister, Greg Hunt, told reporters that the country still had access to 140 million units of coronavirus vaccines — more than enough to cover its population of about 25 million people.

“This is the scientific process working,” Mr. Hunt said. “It’s the planning process working. It’s an honest explanation of some of the challenges we’ve had.”

Carl Zimmer contributed reporting.

Source : https://www.nytimes.com/2020/12/11/world/australia/uq-coronavirus-vaccine-false-positive.html

You must be logged in to comment due to spam issues.